Anandamide serves as an endogenous ligand for which receptor?

Anandamide serves as an endogenous ligand for which receptor?

• A. D2
• B. NMDA
• C. CB1
• D. 5-HT2A

Answer: (C)

Anandamide is part of the endocannabinoid system and acts as an endogenous ligand for the cannabinoid receptor CB1. CB1 is a G-protein–coupled receptor densely expressed in the brain, where its activation by endocannabinoids like anandamide modulates neurotransmitter release and influences mood, pain, appetite, and cognition. When anandamide binds CB1, it typically dampens the release of other neurotransmitters, helping fine-tune neural signaling. The other receptors listed—D2 (dopamine receptor), NMDA (glutamate receptor), and 5-HT2A (serotonin receptor)—are not the primary targets of anandamide, which is why CB1 is the correct choice.

Anandamide is part of the endocannabinoid system and acts as an endogenous ligand for the cannabinoid receptor CB1. CB1 is a G-protein–coupled receptor densely expressed in the brain, where its activation by endocannabinoids like anandamide modulates neurotransmitter release and influences mood, pain, appetite, and cognition. When anandamide binds CB1, it typically dampens the release of other neurotransmitters, helping fine-tune neural signaling. The other receptors listed—D2 (dopamine receptor), NMDA (glutamate receptor), and 5-HT2A (serotonin receptor)—are not the primary targets of anandamide, which is why CB1 is the correct choice.