CBD and THC interact with which system?

CBD and THC interact with which system?

• A. Dopaminergic
• B. Serotonergic
• C. Immune
• D. Endocannabinoid system

Answer: (D)

The key idea is that cannabinoids primarily engage the endocannabinoid system. This system includes receptors like CB1 in the brain and CB2 in the body, the body's own cannabinoid ligands such as anandamide and 2-AG, and the enzymes that synthesize and break them down. THC acts as a partial agonist at CB1, which explains its psychoactive effects, and it can interact with CB2 as well. CBD doesn’t bind strongly to CB1/CB2, but it modulates endocannabinoid signaling in multiple ways, including influencing the breakdown of endocannabinoids and affecting other targets that interact with this system. While dopamine and serotonin pathways can be affected indirectly and immune-related effects can occur through CB2 receptors, the overarching system that cannabinoids directly interact with is the endocannabinoid system.

The key idea is that cannabinoids primarily engage the endocannabinoid system. This system includes receptors like CB1 in the brain and CB2 in the body, the body's own cannabinoid ligands such as anandamide and 2-AG, and the enzymes that synthesize and break them down. THC acts as a partial agonist at CB1, which explains its psychoactive effects, and it can interact with CB2 as well. CBD doesn’t bind strongly to CB1/CB2, but it modulates endocannabinoid signaling in multiple ways, including influencing the breakdown of endocannabinoids and affecting other targets that interact with this system. While dopamine and serotonin pathways can be affected indirectly and immune-related effects can occur through CB2 receptors, the overarching system that cannabinoids directly interact with is the endocannabinoid system.