Drug tolerance causes the dose-response curve to shift to the ______.

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Multiple Choice

Drug tolerance causes the dose-response curve to shift to the ______.

Explanation:
With tolerance, the body becomes less responsive, so you need a higher dose to achieve the same effect. On a dose–response curve, this shows up as a shift to the right—the EC50 (the dose for 50% of the maximal effect) increases, reflecting decreased potency. The overall maximum effect can stay the same unless tolerance also reduces efficacy. So the curve moves to the right.

With tolerance, the body becomes less responsive, so you need a higher dose to achieve the same effect. On a dose–response curve, this shows up as a shift to the right—the EC50 (the dose for 50% of the maximal effect) increases, reflecting decreased potency. The overall maximum effect can stay the same unless tolerance also reduces efficacy. So the curve moves to the right.

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